Journal of Advanced Research

Journal of Advanced Research

Volume 37, March 2022, Pages 267-278
Journal of Advanced Research

Nicotinamide mononucleotide (NMN) as an anti-aging health product – Promises and safety concerns

https://doi.org/10.1016/j.jare.2021.08.003Get rights and content
Under a Creative Commons license
open access

Highlights

  • Provides an overview of promises and safety concerns of NMN as an anti-aging product.

  • Shows that NMN’s beneficial effects supported by in vivo studies.

  • Reveals that there is a lack of NMN’s clinical safety and efficacy studies

  • Suggests that proper clinical investigations are urgently needed on the effectiveness and safety of NMN supplementation.

Abstract

Background

Elderly population has been progressively rising in the world, thus the demand for anti-aging heath products to assure longevity as well as to ameliorate age-related complications is also on the rise. Among various anti-aging health products, nicotinamide mononucleotide (NMN) has been gaining attentions of the consumers and the scientific community.

Aim of review

This article intends to provide an overview on the current knowledge on promises and safety concerns of NMN as an anti-aging health product.

Key scientific concepts of review

Nicotinamide adenine dinucleotide (NAD+) levels in the body deplete with aging and it is associated with downregulation of energy production in mitochondria, oxidative stress, DNA damage, cognitive impairment and inflammatory conditions. However, NMN, as the precursor of NAD+, can slow down this process by elevating NAD+ levels in the body. A number of in vivo studies have indicated affirmative results of therapeutic effects for various age-induced complications with NMN supplementation. One preclinical and one clinical study have been conducted to investigate the safety concerns of NMN administration while a few more human clinical trials are being conducted. As there is a large influx of NMN based anti-aging products on the market, proper clinical investigations are urgently needed to find out the effectiveness and safety of NMN supplementation.

Keywords

Age-induced diseases
Anti-aging
Nicotinamide adenine dinucleotide
Nicotinamide mononucleotide
Supplement

Cited by (0)

Harshani Nadeeshani received her B.Sc. (Hons) degree in Food and M.Phil. degree in Science and Technology from the University of Peradeniya, Sri Lanka. She works as a graduate research assistant at the National Institute of Fundamental Studies (NIFS), Sri Lanka. She is a PhD candidate at Auckland University of Technology (AUT), New Zealand. Her research interests include nutritional biochemistry, functional and nutritional properties of food and nutritional status and malnutrition of Sri Lankan children. She has received “The Best Oral Presentation” awards in three conferences which held in Sri Lanka on food and nutrition.

Professor Jinyao Li is the Dean of Life Sciences, Xinjiang University. The aims of his research are (1) to develop therapeutic cancer vaccines, especially dendritic cell-based vaccine against cervical cancer; (2) to develop vaccines against autoimmune diseases; (3) to search for compounds from natural products for the treatment of cancer, obesity and diabetes. His technical expertise including flow cytometry, small animal experimentation, in vitro tissue experimentation, molecular biology technology and cell line experimentation.

Dr. Tianlei Ying joined the School of Basic Medical Sciences, Fudan University in 2014 as Professor and Chief of the Antibody Engineering and Drug Discovery Laboratory. In the past 5 years, he has published over 50 papers and co-authored over 10 patents and patent applications. Currently, he is involved in the development of novel antibody fragments of small size and long half-lives. He also identified panels of highly potent fully human mAbs against cancer and infectious diseases. Some of these mAbs are expected to move into the clinic shortly.

Baohong Zhang holds a Ph.D. in Marine Biology from Ocean University of China. She had a post-doctoral position in Shanghai Jiao Tong University. Then she works in SJTU over 16 years. She is currently an Assocciate Professor working mainly on biopharmaceuticals in Engineering Research Center of Cell and Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University.

Professor Jun Lu obtained his BSc from East China Normal University and MSc and PhD from the University of Auckland. He established Biomedical Science teaching programme and research laboratory at AUT. His research interest is mainly in nutraceutical products and metabolic disease. He has published more than 120 peer-reviewed journal articles. He has been working on New Zealand seafood products (including mussel, seaweed, paua, fish and clams) to extract bioactive compounds for more than ten years. He is the principal investigator of HVN-funded project mussel-fucoidan as supplemented superfood for the prevention of type 2 diabetes and alleviation of joint pain.

Peer review under responsibility of Cairo University.