Elsevier

FEBS Letters

Volume 584, Issue 9, 3 May 2010, Pages 1923-1930
FEBS Letters

Review
The urokinase receptor: Focused cell surface proteolysis, cell adhesion and signaling

Edited by Sandro Sonnino
https://doi.org/10.1016/j.febslet.2009.12.039Get rights and content
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Abstract

Plasma membrane urokinase-type plasminogen activator (uPA)-receptor (uPAR) is a GPI-anchored protein that binds with high-affinity and activates the serine protease uPA, thus regulating proteolytic activity at the cell surface. In addition, uPAR is a signaling receptor that often does not require its protease ligand or its proteolytic function.

uPAR is highly expressed during tissue reorganization, inflammation, and in virtually all human cancers. Since its discovery, in vitro and in vivo models, as well as retrospective clinical studies have shown that over-expression of components of the uPA/uPAR-system correlates with increased proliferation, migration, and invasion affecting the malignant phenotype of cancer. uPAR regulates the cells–extracellular matrix interactions promoting its degradation and turnover through the plasminogen activation cascade.

Keywords

Urokinase receptor uPAR
Cell migration
Cell adhesion
Cell proliferation
Signaling

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