Laboratory Animal Medicine

Laboratory Animal Medicine (Third Edition)

American College of Laboratory Animal Medicine
2015, Pages 285-349
Laboratory Animal Medicine

Chapter 7 - Biology and Diseases of Other Rodents rights and content

Although rodents of other species account for less than 0.5% of rodents used annually, they have been responsible for insights into biological processes and disease pathogenesis. Many of these rodents have been used in field studies investigating the effect of chemical or physical environmental insults to provide insight into hazards to which humans are exposed. Some rodents have been found to be excellent animal models of parasitic diseases, or natural hosts of viruses that infect humans. A few rodents have unique features that have made them important models for aging, cancer or metabolic diseases. In this chapter we describe the research use, biology, husbandry, acquired and spontaneous diseases of ground squirrels (Spermophilus), prairie dogs (Cynomys), pocket gophers (Geomyidae), kangaroo rats (Dipodomys), pack rats (Neotoma), grasshopper mice (Onychomys), deer mice (Peromyscus), rice rats (Oryzomys), cane mice (Zygodontomys), cotton rats (Sigmodon), white-tailed rats (Mystromys), gerbils (Meriones), voles (Microtus), multimammate rats (Mastomys), degus (Octodon) and naked mole rats (Heterocephalus).

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    Reports of neoplastic disease in degus are rare. Only a few single case reports have been published, including renal transitional cell carcinoma, vaginal leiomyosarcoma, uterine angioleiomyoma, bronchioalveolar carcinoma, lymphoma, hepatocellular carcinoma, splenic hemangioma, and mesenteric lipoma.1,6,7,9,10 As stated previously, the authors were unable to find another report describing a chordoma in a degu, or any member from the family Octodontidae.

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